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1. Choose between: is/are

Antiviral therapy with acyclorir or with one of the longer acting anti-HSV medications __________ most effective in decreasing the pain and duration of symptoms.

‘with acyclorir or with one of the longer acting anti-HSV medications ‘ acts as a prepositional phrase. We can test this by looking at the sentence without this phrase.

Antiviral therapy is most effective in decreasing the pain and duration of symptoms.

Therefore the answer is ?

As I understand it, the basic sentence is:

Antiviral therapy __________ most effective in decreasing the pain and duration of symptoms.

And the verb should therefore be IS:

Antiviral therapy with acyclorir or with one of the longer acting anti-HSV medications IS most effective in decreasing the pain and duration of symptoms.

Is

is used for a single person and are Is used for many people

For Example
He is going to school
We are going to School
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